About the PI

Adrienne M. Dorrance Ph.D.

It all started when…

I took my first developmental biology class and wondered into Dr. Michael Caligiuri’s lab as an undergraduate at Ohio State University (OSU). My project while in Dr. Caligiuri’s Lab was focused on understanding the role of the unique gene rearrangement known as the partial tandem duplication of the MLL (KMT2A) gene. After graduating with my Ph.D. I joined the lab of Dr. David A. Williams at Childrens’ Hospital Boston, Harvard Medical School. During this time I focused on the regulation of normal hematopoietic stem cell functions such as migration and adhesion during bone marrow transplantation and engraftment. I returned to OSU after my time in Boston to join Dr. Marcucci’s lab, where I investigated the role of microRNAs (miRs) in acute myeloid leukemia stem cells. Currently my group at OSU investigates the role of unique proteins and non-coding RNAs in the regulation of both normal and malignant stem cells. Our goal is to find better targeted therapies and eliminate the need for toxic chemotherapies to treat hematologic malignancies.

In my free time I like running, pilates, skiing, and taking care of my four dogs.